Joe Burrow dominated the injury headlines last week, and for good reason. But several other players quietly picked up injuries that could shape Week 3 and beyond. Below, we break down the most important NFL Week 3 injury updates and their fantasy football outlooks. With injuries having a massive impact on start/sit decisions, this analysis will give you the edge to set winning lineups.

Quarterbacks

Brock Purdy

Injury: Shoulder / Toe Injury

Analysis: Purdy has progressed well over the past week, but is not expected to start in week 3. The toe injury is the biggest concern for Purdy. Shanahan has purposely not revealed which toe is injured, but video review shows a right big toe getting smushed under the defender. A right big toe injury can impact a quarterback's ability to push off when throwing. Whenever Purdy can go, his pocket mobility and deep balls may be limited initially.

Baker Mayfield

Injury: Left Knee / Foot/Toe

Analysis: Mayfield appeared to injure his left knee during Monday night's game. He finished the game, and there have been no official reports of his knee being an issue. At this point, his knee is just something to monitor. He is also dealing with a foot/toe issue, but full practices suggest this is mild and won't negatively impact him in week 3.

Jayden Daniels

Injury: Left knee

Analysis: Daniels will miss week 3 with a knee injury. Video review is concerning for a mild PCL injury. In the long run, Daniels should be fine and can play through it, but in the short term, PCL injuries affect stability and confidence when planting and cutting off the injured leg. For a running QB like Daniels, expect limited rushing production over the first few weeks after he returns; his throwing should remain strong.

Justin Fields

Injury: Concussion

Analysis: Fields has been ruled out with a concussion. He will need to pass through the NFL's protocol to play in week 4.

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JJ McCarthy

Injury: High Ankle Sprain

Analysis: McCarthy suffered a right high ankle sprain while scrambling on Sunday night and is expected to miss 2-4 weeks, indicating a grade 2 injury with some tissue damage and instability. High ankle sprains cause instability where the lower leg meets the foot, which can make it difficult to plant and power off the injured ankle. For a right-handed quarterback, this can impact his throwing power as well as mobility.

Quarterbacks average missing 1.6 games; McCarthy is expected to exceed this. The good news is that historically, quarterbacks average no drop-off in fantasy points after a high ankle sprain.

Running Backs

Josh Jacobs

Injury: Ankle Injury

Analysis: Jacobs opened the week on the injury report but has since been cleared. Three limited practices suggest a mild issue that shouldn’t impact his fantasy upside. While ankle sprains carry a 29% recurrence rate, running backs average only an 8% dip in production. Jacobs’ upside is strong enough that this shouldn’t concern fantasy managers.

Cam Skattebo

Injury: Ankle Injury

Analysis: Skattebo was initially listed as questionable with an ankle injury, but logged three full practices. Ankle sprains will impact a runner's lateral agility much more than the downhill bruising style of running Skattebo is known for. This does not appear to be an injury that would negatively impact Skattebo this week. The rookie has looked impressive through two weeks and may be on his way to securing a larger role in the Giants' offense.

Tyrone Tracy

Injury: Calf / Rib

Analysis: Tracy is off the injury report after limited practices with calf and chest issues. Calf injuries (15–20% recurrence) can impact speed and acceleration, while chest injury recurrences are rarer. Both can cause mild fantasy dips, but being fully cleared lowers concern. The bigger threat may be Cam Skattebo stealing touches.

Bhayshul Tuten

Injury: Shoulder Injury

Analysis: Tuten is cleared to play after a mild shoulder injury. Running backs average a 19% dip in fantasy production in the first game after a shoulder injury. Tuten's appears very mild, so he may not see such a significant dip and remains in flex consideration in deep leagues.[-

Zach Charbonnet

Injury: Foot Injury

Analysis: Foot injuries can impact a running back's ability to plant and change direction quickly. When mild, these usually are not a big problem, but when moderate-severe, they can linger and worsen throughout the year. Charbonnet did not practice all week and was ruled out on Friday. It's too early to tell where he falls on the severity spectrum, but monitoring progress next week will be very telling.

D’Andre Swift

Injury: Quad Injury

Analysis: Swift was limited in practice all week with a quad injury. The quads are among the strongest muscles in the body and play a key role in sprinting and initiating contact. Surprisingly, players can often compensate for mild quad injuries, with running backs showing no average drop-off in fantasy production upon return. Backs typically miss about 1.2 games, though many don’t miss any. Re-injury remains a concern, with rates around 10–15%. If Swift ends up playing, he remains a worthwhile start. The challenge for fantasy managers is that Swift plays at 4:25, so you must have a pivot option ready.

Jeremy McNichols

Injury: Hamstring

Analysis: McNichols is good to go in week 3 after battling a mild hamstring injury. Hamstrings are a powerful sprinting muscle that is most active at the top 80-100% of a sprint. Running backs only get to top speed on long runs, which helps explain why backs see no drop-off in fantasy points after a hamstring injury. The big concern is re-injury, which is a 20-30% risk.

Wide Receivers

Ladd McConkey

Injury: Biceps Injury

Analysis: McConkey logged two full practices and will play with no restrictions. A mild biceps injury like this is not going to affect his ability to run or move his arm to make all the catches. These types of injuries are more impactful on weight-lifting moves, but not actual football plays. McConkey is off to a slower start this season, but the Chargers' offense is powerful and should continue to put up yards and touchdowns in bunches. McConkey's time is coming.

Brian Thomas Jr.

Injury: Wrist Injury

Analysis: Brian Thomas Jr. is dealing with a mild wrist injury, but has been a full participant in practice. An injury this mild is unlikely to affect his ability to catch and hold the ball. This is a non-concern for now and is not why Thomas is off to a slow start.

Emeka Egbuka

Injury: Groin / Hip Flexor Injury

Analysis: Egbuka is truly questionable after being limited in practice on Friday after missing two practices earlier in the week. The groin muscles are involved in sprinting and single-leg function, but are not the primary drivers for speed and power. He is also reportedly dealing with a hip injury, which can also influence sprinting. Historically, receivers average missing just one game and no drop-off in fantasy production when they return from both groin and hip muscle injuries; however, his limitations in practice may lead to a reduction in snaps and fewer opportunities. Egbuka has been excellent through two weeks, but this may be a week to keep him on the bench even if he plays.

Xavier Worthy

Injury: Shoulder Dislocation

Analysis: Worthy is not expected to play in week 3 as he rehabs a shoulder dislocation with a labrum tear. The risk of re-dislocation is very high, with NFL data showing a 55% recurrence rate. Another dislocation could mean an extended time out or even season-ending surgery. Whenever he does play, expect Kansas City to utilize him as a deep threat and space creator, while limiting his contact as his shoulder recovers strength. Worthy will carry a high risk all season with the chance of re-dislocation at any time. With the Chiefs playing Sunday night, fantasy managers need a pivot ready if they plan to start him.

Jauan Jennings

Injury: Ankle Injury

Analysis: Jennings missed practice all week while rehabbing an ankle injury. These injuries limit route sharpness and separation, with recurrence rates in the high 20s. Even if he suits up, he’ll likely be limited. WRs average a 14% dip in fantasy points after an ankle injury, and that likely applies to Jennings.

Josh Downs

Injury: Ankle Injury

Analysis: Unlike Jennings above, Downs has practiced in full and is off the injury report. Expect him to look good and not see the typical 14% decline in fantasy points.

Christian Kirk

Injury: Hamstring

Analysis: Kirk is expected to return in Week 3 after missing two games with a hamstring injury. Because hamstrings are critical for sprinting, wide receivers are impacted more than any other position, averaging a 15% dip in fantasy production and carrying a 20–30% re-injury risk. That said, Kirk’s slot role is exactly what Houston needs right now, and with C.J. Stroud looking to get the ball out quickly, he could still see a high volume of targets this week.

Wan'Dale Robinson

Injury: Foot Injury

Analysis: Foot injuries often will impact a receiver's ability to get in and out of his routes and, when moderate-severe, can linger all season. Robinson was a full go in practice, making it likely his injury is mild and should not have the negative impacts mentioned above.

Xavier Legette

Injury: Hamstring

Analysis: Legette is dealing with a mild hamstring injury. The words of coach Canalles are not very concerning; however, Legette has not shown fantasy value yet in his young career and is best kept on the bench/waivers.

Tory Horton

Injury: Groin Injury

Analysis: Horton is cleared to play after a mild groin injury. Groin injuries can impact a players stability on one leg but are less involved in changing directions, likely why receivers average no decline in fantasy points after a groin injury.

Tight Ends

Tyler Warren

Injury: Toe Injury

Analysis: Warren was limited in practice on Thursday and Friday as he deals with a toe injury but will play. Toe injuries can impact a player's ability to push off while sprinting and blocking. The sample size for tight ends is too small, but receivers average a 10% dip in fantasy points after a toe injury. Expect him to be a little less explosive but still worth a start.

Kyle Pitts

Injury: Toe Injury

Analysis: Unlike Warren above, Pitts has been a full practice participant and is off the injury report. Do not expect this to limit Pitts this week.

Tucker Kraft

Injury: Knee

Analysis: Kraft suffered an undisclosed knee injury in practice and is questionable for Sunday. The team has not provided much detail but we know they do not think it is serious. For now, we will continue to look out for more information.

Dallas Goedert

Injury: Knee Injury

Analysis: Goedert will return this week after missing week 2 with a knee injury. Expect Goedert to look good overall, but may be a little less explosive than usual.

Evan Engram

Injury: Back Injury

Analysis: Engram is out with a back injury.