Week 4 gave us more brutal losses to big-name players. Tyreek Hill and Malik Nabers' seasons are over, with the former's career in jeopardy. Lamar Jackson and Brock Purdy are banged up, and a number of other key players are dealing with new issues heading into week 5. If you are a fantasy football player, you most likely have several players injured by this point, making it critical to read the article below and follow along to help navigate the injury landscape.

Quarterbacks

Lamar Jackson

Injury: Hamstring injury

Analysis: Jackson's week 5 status is in question with a right hamstring injury. Jackson would be doubly affected by a hamstring injury. First, this is the leg he powers off to throw. A grade II hamstring injury is associated with loss of muscle strength, which could impact his throwing power. Secondly, he obviously does a lot of damage on the ground, and top speed is affected by hamstring injuries.

The final concern is re-injury. The hamstring is the most common muscle to have recurring injuries (studies show 20-30% will re-injure). The Ravens are 1-3 and must start to string together wins soon, which may force Jackson to play sooner than he should. For now, we will monitor his practice status this week and provide more analysis in Saturday's article.

Brock Purdy

Injury: Toe injury

Analysis: Purdy's toe is apparently sore after Sunday's game. This is not unexpected, as he returned on the short end of his estimated absence, indicating he likely was not at 100%. Toe injuries tend to recur, and this may be what Purdy is dealing with. He played well on Sunday, and if he can play again this week, I would expect the same. San Francisco plays Thursday night, which will complicate things.

Jaxson Dart

Injury: Hamstring injury

Analysis: Dart is dealing with a mild hamstring injury but is expected to practice on Wednesday. A quick turnaround indicates no worse than a grade I injury with minimal muscle damage and next to no loss of strength or range of motion. Re-injury risk will still be a concern, though, being just 22 years old, healing is highly efficient.

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Running Backs

Bucky Irving

Injury: Undisclosed injury

Analysis: Irving underwent an MRI on Monday for an undisclosed injury. We will await further details and provide an in-depth analysis in Saturday's article.

Braelon Allen

Injury: Knee injury

Analysis: Allen took a shot to the lateral knee while returning a kick on Monday night. Official word on the injury has not been released, but the video review is highly concerning for an MCL injury. Allen's foot was planted as he absorbed the shot to the outside of the knee, causing a valgus moment, which stresses the knee. If this holds true, RBs average missing three games and see a 13% dip in fantasy points upon return.

Miles Sanders

Injury: Ankle injury

Analysis: Sanders suffered a mild ankle injury but is expected to be fine. Ankle injuries impact a runner's lateral agility and have high recurrence rates (>20%). Running backs average a 7% dip in fantasy points after an ankle sprain.

Wide Receivers

Tyreek Hill

Injury: Knee dislocation

Analysis: Hill suffered a brutal knee dislocation on Monday night and was rushed to the hospital. The immediate concern is for neurovascular integrity as the popliteal artery runs down the back of the knee and is at risk for being severed with an injury like Hill's. This morning, we have received no indication that Hill underwent emergency surgery, meaning these structures are safe. We know Hill tore his ACL; multiple other tissues are also torn and in need of repair. Hill will certainly miss the rest of 2025, and his 2026 status is in question. At 31 years old, this will not be an easy rehab, and he may never fully regain his elite speed.

Malik Nabers

Injury: ACL tear

Analysis: Nabers tore his ACL while attempting to jump for a catch. Video shows his right foot planting far outside his base of support, and you can see his knee buckle and create a valgus moment where the knee bends inward until you see the tibia pop inward, which occurs when the ACL tears.

So what about Nabers' 2026 status? Historically, receivers struggle in year one after an ACL tear, averaging a 28% decline in fantasy points per game compared to the prior season. However, some outliers played extremely well in year one post-ACL. Nabers has a number of factors in his favor to be one of these outliers. Presently, reports are only stating the ACL is injured; if he avoided damage to any other tissues, rehab will be much quicker. He is only 22 years old; he literally will never have a more efficient biology for healing than right now. He will have the better part of 10.5-11 months to rehab before week one. This is a realistic timeline. And lastly, he is an absolute freak athlete. There is a long road ahead for Nabers, but he has as good a chance as any to come back strong in year one.

Calvin Ridley

Injury: Undisclosed injury

Analysis: Ridley is dealing with an undisclosed injury. We will monitor his status and provide more analysis in Saturday's article.

Darnell Mooney

Injury: Hamstring injury

Analysis: Mooney exited Sunday's game with a hamstring injury but is unlikely to miss any games. Atlanta has a bye in week 5, which creates an additional week buffer. Even still, the short expected absence tells us this is likely a grade I injury with no true loss of strength. This should allow Mooney to play well when he returns. Re-injury risk is still present.

Ricky Pearsall

Injury: PCL sprain

Analysis: Pearsall landed on his right knee with his knee flexed, a mechanism for a PCL injury. Pearsall attempted to return but reported feeling unstable and did not finish the game. The PCL is a passive knee stabilizer, helping keep the shin and thigh bones congruent with one another. The PCL is also loaded with proprioceptors, meaning it has an extremely large sensory role in the body's ability to know where its leg is in space. The role of proprioception is critical for an athlete's ability to quickly change directions without looking at the ground.

Players can play through a grade I PCL injury, but they often look slow in the first few games. No better example than Brock Bowers, who has not looked himself since his week one PCL injury. San Francisco has a Thursday night game this week, which would make it extremely unlikely that Pearsall can play. When he does return, expect a few games of below his average production before returning to his norm.

Cedric Tillman

Injury: Hamstring injury

Analysis: Tillman is expected to miss numerous weeks with a hamstring injury, indicating a grade II injury with true muscle damage, loss of strength, and range of motion. Receivers average missing 1.9 games and average a 15% drop in fantasy points when they return from injury. Tillman can likely be dropped in most formats.

Calvin Austin

Injury: Shoulder injury

Analysis: Austin injured his shoulder in Dublin, an injury that resulted in a trip to the hospital. Austin later posted on X that he was okay. Exact details and severity have yet to be revealed as the Steelers head into their bye week.

Jauan Jennings

Injury: Rib injury

Analysis: Jennings took an absolute shot to the right side of his ribs on Sunday and is questionable for Thursday night's game. Playing through rib injuries tends to be more about pain tolerance than anything; however, it is important to note that several key muscles that a receiver needs to use attach to the ribs. The pecs, lats, obliques, and serratus anterior muscles are all critical for running, twisting the torso, and raising the arm to catch a ball. When the muscles contract, they pull on the rib bones, which can be extremely painful.

Receivers average missing less than one game due to injury, but see a 15% drop-off in fantasy points. With San Francisco playing Thursday night, this would be a quick turnaround for Jennings.

Tight Ends

No reported tight end injuries from this list.